(引用 typhoonzj:关于这次发生突变的S1 subunt S2 subunit的 Delta上几个图便于理解 )简单说，mRNA疫苗促动病毒变异？。。zzxz 　[本文发送自华新iOS APP] [Blzrd (8-6 9:29, Long ago)] [ 传统版 | sForum ][登录后回复]21楼

(引用 typhoonzj:关于这次发生突变的S1 subunt S2 subunit的 Delta上几个图便于理解 )S 蛋白



[typhoonzj (8-6 9:29, Long ago)] [ 传统版 | sForum ][登录后回复]22楼

(引用 typhoonzj:S 蛋白 ...)更多信息https://www.nature.com/articles/d41586-021-02039-y
[typhoonzj (8-6 9:32, Long ago)] [ 传统版 | sForum ][登录后回复]23楼

(引用 typhoonzj:更多信息https://www.nature.com/articles/d41586-021-02039-y )delta为什么更危险，因为S蛋白突变，而且还有其他未知因素More furin cuts mean more spike proteins primed to enter human cells. In SARS-CoV, less than 10% of spike proteins are primed, says Menachery, whose lab group has been quantifying the primed spike proteins but is yet to publish this work. In SARS-CoV-2, that percentage rises to 50%. In the Alpha variant, it’s more than 50%. In the highly transmissible Delta variant, the group has found, greater than 75% of spikes are primed to infect a human cell.

Known unknowns
The scientific community is still scratching the surface of its understanding of SARS-CoV-2. Key unknowns include the number of ACE2 receptors needed to bind to each spike protein; when exactly the S2 site is cleaved by TMPRSS2; and the number of spikes needed for virus–cell membrane fusion, says McLellan — and that’s just for entry. In April 2020, a team at the University of California, San Francisco, identified at least 332 interactions between SARS-CoV-2 and human proteins25.

It is not easy to keep pace with the quickly mutating virus. Most mutations so far are associated with how effectively the virus spreads, not with how much the virus damages the host, experts agree. This month, a study reported that the Delta variant grew more rapidly and at higher levels inside people’s lungs and throats than did earlier versions of the virus26.

But it is not yet certain how Delta’s mutations have supercharged the variant in this way, says Stern-Ginossar. “This is something many labs are trying to figure out.”[typhoonzj (8-6 9:35, Long ago)] [ 传统版 | sForum ][登录后回复]24楼

RAN是什么呀？ 　[本文发送自华新iOS APP] [南洋的云 (8-6 9:37, Long ago)] [ 传统版 | sForum ][登录后回复]25楼

(引用 Blzrd:简单说，mRNA疫苗促动病毒变异？。。zzxz)Delta出现在印度印度使用MRNA的比率应该是蛮低的，不过从选择角度看，专对这个S蛋白干，确实会导致S蛋白变异体更多存活下来[typhoonzj (8-6 9:39, Long ago)] [ 传统版 | sForum ][登录后回复]26楼

(引用 南洋的云:RAN是什么呀？)疫苗的昵称吧，俺感觉。zzz 　[本文发送自华新iOS APP] [Blzrd (8-6 9:40, Long ago)] [ 传统版 | sForum ][登录后回复]27楼

(引用 typhoonzj:Delta出现在印度印度使用MRNA的比率应该是蛮低的，不过从选择角度看，专对这个S蛋白干，确实会导致S蛋白变异体更多存活下来)delta很快从印度转战到了美国，然后美国现在貌似已经很了解疫苗对病毒反向影响了 　[本文发送自华新iOS APP] [Blzrd (8-6 9:43, Long ago)] [ 传统版 | sForum ][登录后回复]28楼

(引用 Blzrd:简单说，mRNA疫苗促动病毒变异？。。zzxz)纳尼？ 这是什么逻辑呢？[笑天 (8-6 9:44, Long ago)] [ 传统版 | sForum ][登录后回复]29楼

(引用 笑天:纳尼？ 这是什么逻辑呢？)俺的逻辑，从来都会被您质疑的吧哈哈哈 　[本文发送自华新iOS APP] [Blzrd (8-6 9:45, Long ago)] [ 传统版 | sForum ][登录后回复]30楼

(引用 Blzrd:俺的逻辑，从来都会被您质疑的吧哈哈哈)是疑问求知OK？[笑天 (8-6 9:50, Long ago)] [ 传统版 | sForum ][登录后回复]31楼

(引用 Blzrd:简单说，mRNA疫苗促动病毒变异？。。zzxz)真搞笑 一天几万几万的感染才是变异的主因 　[本文发送自华新iOS APP] [功夫熊猫 (8-6 9:52, Long ago)] [ 传统版 | sForum ][登录后回复]32楼

(引用 笑天:是疑问求知OK？)哎呀，您对俺要求太高，难道要逼俺读paper再来反馈？也不是不可以啦，不过俺的理解能力也只是有限级嘿嘿 　[本文发送自华新iOS APP] [Blzrd (8-6 9:52, Long ago)] [ 传统版 | sForum ][登录后回复]33楼

很难懂？核酸可分为核糖核酸（简称RNA）和脱氧核糖核酸（简称DNA）。DNA是储存、复制和传递遗传信息的主要物质基础，RNA在蛋白质合成过程中起着重要作用
[笑天 (8-6 9:57, Long ago)] [ 传统版 | sForum ][登录后回复]34楼

ship同学，生物课开始了哟 　[本文发送自华新iOS APP] [Blzrd (8-6 10:01, Long ago)] [ 传统版 | sForum ][登录后回复]35楼

(引用 功夫熊猫:真搞笑 一天几万几万的感染才是变异的主因)嗯，疫苗还得加紧继续打。zzzz 　[本文发送自华新iOS APP] [Blzrd (8-6 10:03, Long ago)] [ 传统版 | sForum ][登录后回复]36楼

自己没读过书以为大家都没读过。。。[阿拉玛 (8-6 10:04, Long ago)] [ 传统版 | sForum ][登录后回复]37楼

不是每个网友都和兄弟你一样的吧[笑天 (8-6 10:04, Long ago)] [ 传统版 | sForum ][登录后回复]38楼

(引用 阿拉玛:自己没读过书以为大家都没读过。。。)首先俺不确定ship同学读书的水准，不过读了多少书又怎样？全世界都围着这个病毒转了快两年，全球的理解力加起来都没有病毒变异速度快。。zzz 　[本文发送自华新iOS APP] [Blzrd (8-6 10:08, Long ago)] [ 传统版 | sForum ][登录后回复]39楼

额，本来想说ship同学是博士，俺也不奇怪哈哈哈 　[本文发送自华新iOS APP] [Blzrd (8-6 10:12, Long ago)] [ 传统版 | sForum ][登录后回复]40楼