There is a file in my comp that can not be deleted!

When i tried to deleted it, system told me :

Cannot delete filename: It is being used by another person or program. Close any programs that might be using the file and try again!

But actually, i was trying to delete it as soon as I logged in my comp. There is no difference when i restart!

Some ppl can help me!
Thank you in advance!

as you restart, press F8, then choose safe mode, then delete, normally work...

我当时也是没办法，不过过了几天我再去delete它，就成功了。
有好几次都是这样的，当时delete不了，我就放着，过几天再去delete，遇到过七八次这样的情况，成功率100%。个人觉得这个方法，--最笨。没办法，谁叫我不会别的呢。