我的理解跟你的有点不同
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作者:watercooler (等级:14 - 天人和一,发帖:12846) 发表:2003-08-30 20:16:49  楼主  关注此帖评分:
向Life Science的筒子请教正在啃一门USP的课Brain and Cognition,问题是: What two functions do proteins in the neural membrane serve to establish and maintain the resting membrane potential? 除了那个著名的Na-K Pump,还有另一个protein function是什么呢?是不是其他protein channels, the Na+ or K+ or Ca2+ gates统统并在一类里算是另一个function carried out by proteins? 但书上没有这样子划分的...向专业的筒子请教——谢谢~~~
我的理解跟你的有点不同
其实, 拿NA-K PUMP来做例子, 他是一个PROTEIN, 但是SERVE TWO FUNCTIONS, 一个是要ESTABLISH AND MENTAIN CHEMICAL POTENTIAL, ANOTHER IS FOR ELECTRICAL POTENTIAL.3 SODIUM IONS ARE PUMPPED OUT WHEN 2 POTASSIUM IONS ARE PUMPPED IN. SO BOTH CHEMICAL (NA OUTSIDE AND K INSIDE) AND ELECTRICAL (3-2) POTENTIAL ARE ALTERED. AND THERE ARE MANY OTHER PROTEINS, ION CHANNELS MAY FUNCTION AT THE SAME TIME FOR FINE TUNE OR SIGNALING. THEY MAY HELP IN ESTABLISHING ONE OR BOTH POTENTIALS. SO, IT IS NOT ABSOLUTE THAT ONE PROTEIN ONLY HAS ONE FUNCTION. AND IT IS SURE THAT MANY PROTEINS CONTRIBUTE TO ONE SAME FUNCTION.
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作者:watercooler (等级:14 - 天人和一,发帖:12846) 发表:2003-08-30 20:21:15  2楼
I am not a professional, but let me try to answer.Pls correct me if I make any mistakes. My memory is already abit hazy cos I took this course in my first year. Other than the sodium potassium pump, the presence of ion channels provides a way for the ions to diffuse through the membrane under the influence of both concentration forces and electrostatic forces. This diffusion helps to balance the membrane potential in the resting state. Ion channels are in fact protein molecules. This might be the thing that your lecturer talked about.
i think you got the idea of this question
but you used the term "diffuse" wrongly:). ions cannot diffuse through the membrane. "diffuse" means there are no facilitated channels needed and it means the substrate molecules cross the barrier spontaneously.
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作者:watercooler (等级:14 - 天人和一,发帖:12846) 发表:2003-09-01 11:42:29  3楼 评分:
现在我心里有数多了,谢谢谢谢~~~还有啊watercooler,那种Protein Channel在Campbell的课本上也叫做Facilitated Diffusion,算是Passive Transport,当然有别于Simple Diffusion。谢谢你的答案,确实是用另一个角度来看这个问题。 :)))
passive transport can be called diffussion
but this faciliated diffusion does not function to the maintenance and establish this potential. or I should say, it does contribute to the equilibrium of the ion concentration on two sides, but the sensing proteins which really function for potentials are not them.
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