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Regulatory sequences (e.g., transcription factor binding sites), unlike protein-coding regions, are subject to rapid turnover. Õâ¾ä»°À´×Ô(Webb Miller et.al., "Comparative Genomics", annual review of Genomics and Human Genetics Vol.5:15-56)
Õâ¾ä»°ºóÃæ¸úÁËreference¡£ÔÚreference38µÄabstractÖУ¬×÷ÕßÌáµ½£º"estimated that 32%-40% of the human functional sites are not functional in rodents. This is evidence that there is widespread turnover of transcription factor binding sites"
ÔÚintroductionÖУ¬×÷Õß˵µ½:"Individual binding sites may exhibit relatively little conservation, either because of the degeneracy of the transcription factor binding requirements or because their small size makes it relatively likely that a new functional site will arise by chance."
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