¹ØÓÚlife scienceµÄÎÊÌ⣺regulatory sequence - turnover and degenerate nature
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ÎÒ¾õµÃÓÐÏàͬµÄÒâ˼µ«turnoverÖ¸µÄÓ¦¸Ã²»ÊÇsequence±¾ÉíµÄ±ä»¯£¬¶øÊÇÒ»¸öregulatory sequence±»ÁíÒ»¸öregulatory sequenceËùÈ¡´ú¡£ Regulatory sequences (e.g., transcription factor binding sites), unlike protein-coding regions, are subject to rapid turnover. Õâ¾ä»°À´×Ô(Webb Miller et.al., "Comparative Genomics", annual review of Genomics and Human Genetics Vol.5:15-56) Õâ¾ä»°ºóÃæ¸úÁËreference¡£ÔÚreference38µÄabstractÖУ¬×÷ÕßÌáµ½£º"estimated that 32%-40% of the human functional sites are not functional in rodents. This is evidence that there is widespread turnover of transcription factor binding sites" ÔÚintroductionÖУ¬×÷Õß˵µ½:"Individual binding sites may exhibit relatively little conservation, either because of the degeneracy of the transcription factor binding requirements or because their small size makes it relatively likely that a new functional site will arise by chance." ËùÒÔÎÒµÄÀí½âÊÇ£¬TurnoverÖ¸µÄÊÇÒ»¸öregulatory sequence±»ÁíÒ»¸öregulatory sequenceËùÈ¡´ú¡£ ÔÚ½ø»¯ÖУ¬ÓÉÓÚregulatory sequenceÏà¶Ô½Ï¶Ì£¬ÒÔ¼ (more...)
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